Historically, Panzano has found itself battered repeatedly. Located almost directly in the middle of the constantly feuding powers of Siena and Florence, it was destroyed in 1260 and again in 1397 and then again in the 1400’s and 1500’s when it changed hands back and forth between Florence and Siena. What remains of the original medieval center is now incorporated in the bell tower of the church in the Panzano Alto.